Detalhe da pesquisa
1.
AAV-mediated neuronal expression of an scFv antibody selective for Aß oligomers protects synapses and rescues memory in Alzheimer models.
Mol Ther
; 31(2): 409-419, 2023 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36369741
2.
Amyloid ß Proteoforms Elucidated by Quantitative LC/MS in the 5xFAD Mouse Model of Alzheimer's Disease.
J Proteome Res
; 22(11): 3475-3488, 2023 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37847596
3.
Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain.
Proc Natl Acad Sci U S A
; 117(12): 6844-6854, 2020 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32144141
4.
Intrathecal amyloid-beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's disease.
Neuropathol Appl Neurobiol
; 48(4): e12800, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35156715
5.
An Essential Role for Alzheimer's-Linked Amyloid Beta Oligomers in Neurodevelopment: Transient Expression of Multiple Proteoforms during Retina Histogenesis.
Int J Mol Sci
; 23(4)2022 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35216328
6.
Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer's patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability.
Neuropathol Appl Neurobiol
; 47(4): 488-505, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33119191
7.
Antibody Fragments as Tools for Elucidating Structure-Toxicity Relationships and for Diagnostic/Therapeutic Targeting of Neurotoxic Amyloid Oligomers.
Int J Mol Sci
; 21(23)2020 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33255488
8.
A novel crosslinking protocol stabilizes amyloid ß oligomers capable of inducing Alzheimer's-associated pathologies.
J Neurochem
; 148(6): 822-836, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30565253
9.
Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers.
Eur J Neurosci
; 49(9): 1091-1101, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30565792
10.
The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease.
J Pathol
; 245(1): 85-100, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29435980
11.
Amyloid-ß oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons.
J Biol Chem
; 292(18): 7395-7406, 2017 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28302722
12.
A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-ß oligomers.
J Neurochem
; 142(6): 934-947, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28670737
13.
Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.
Acta Neuropathol
; 134(5): 769-788, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28612290
14.
Rifampicin is a candidate preventive medicine against amyloid-ß and tau oligomers.
Brain
; 139(Pt 5): 1568-86, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27020329
15.
Alzheimer's Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station.
Yale J Biol Med
; 90(1): 45-61, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28356893
16.
Neuronal amyloid-ß accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease.
Brain
; 138(Pt 6): 1722-37, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25732182
17.
A Study of Aß Oligomers in the Temporal Cortex and Cerebellum of Patients with Neuropathologically Confirmed Alzheimer's Disease Compared to Aged Controls.
Neurodegener Dis
; 16(5-6): 398-406, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27400224
18.
Alzheimer's disease-like pathology induced by amyloid-ß oligomers in nonhuman primates.
J Neurosci
; 34(41): 13629-43, 2014 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25297091
19.
Amyloid ß oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis.
Acta Neuropathol
; 129(2): 183-206, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25604547
20.
Memantine rescues transient cognitive impairment caused by high-molecular-weight aß oligomers but not the persistent impairment induced by low-molecular-weight oligomers.
J Neurosci
; 33(23): 9626-34, 2013 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23739959